Seronegative arthritis refers to the following inflammatory arthritis types: psoriatic arthritis, reactive arthritis, palindromic rheumatism, ankylosing spondylitis, and enteropathic arthritis. These arthritis types have a common characteristic: blood tests do not show rheumatoid factor (a specific antibody).
The common symptoms include: joint stiffness, lower back pain, joint inflammation, tendon inflammation, finger and toe inflammation, eye inflammation, skin ulcers, mouth ulcers, or extreme fatigue.
Without a rheumatoid factor, detecting the inflammation is difficult. But rheumatologist doctors can often make other tests and diagnosis.